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Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury

  • Arthur I. Cederbaum
  • , Yongke Lu
  • , Xiaodong Wang
  • , Defeng Wu

Research output: Contribution to journalArticlepeer-review

Original languageAmerican English
JournalPharmacology, Physiology and Toxicology
StatePublished - Jan 1 2015

Keywords

  • Alcohol liver
  • injury CYP2E1-dependent toxicity
  • Lipopolysaccharide–CYP2E1 interactions
  • Oxidative stress and liver injury
  • CYP2E1-tumor necrosis factor alpha toxicity
  • JNK and p38 mitogen-activated kinases
  • Mitochondrial dysfunction

Disciplines

  • Chemical and Pharmacologic Phenomena
  • Hepatology
  • Medical Sciences
  • Medical Specialties
  • Medicine and Health Sciences

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