Abstract
BACKGROUND: Childhood obesity increases cardiovascular risk during adulthood. Retinol-binding protein-4, a pro-inflammatory adipokine, associated with obesity and insulin resistance also plays a role in atherogenesis in adults. The goal of this study was to identify the relation between RBP4 and atherogenic markers in obese children.
METHODS: In a cross-sectional study, obese and non-obese children (8-18 years) were prospectively recruited from a pediatric Appalachian population. Clinical markers such as lipid profile, HbA1c, markers of insulin resistance and plasma levels of RBP4, sVCAM-1 and oxidized-low-density lipoprotein (Ox-LDL) were measured.
RESULTS: Compared to non-obese children, RBP4 (P=0.016) and Ox-LDL (P<0.001) were significantly higher in obese children and were positively correlated with Body Mass Index (P<0.001), BMI-SDS (Standard-Deviation Score) (P<0.001) and waist circumference (P=0.03).
CONCLUSIONS: No significant correlation was found between inflammatory markers and Homeostatic Model Assessment-2, HDL, triglycerides, and HbA1c in obese children.
| Original language | English |
|---|---|
| Pages (from-to) | 291-7 |
| Number of pages | 7 |
| Journal | Minerva endocrinologica |
| Volume | 41 |
| Issue number | 3 |
| State | Published - Sep 2016 |
Keywords
- Adolescent
- Atherosclerosis/blood
- Biomarkers/blood
- Body Mass Index
- Child
- Cross-Sectional Studies
- Female
- Humans
- Lipoproteins, LDL/blood
- Male
- Pediatric Obesity/blood
- Puberty
- Retinol-Binding Proteins, Plasma/analysis
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