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AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice.

  • Lili Wang
  • , Peter Bell
  • , Hiroki Morizono
  • , Zhenning He
  • , Elena Pumbo
  • , Hongwei Yu
  • , John White
  • , Mark L Batshaw
  • , James M Wilson
  • George Washington University

Research output: Contribution to journalArticlepeer-review

Original languageAmerican English
JournalGenomics and Precision Medicine Faculty Publications
Volume120
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Aging
  • Animals
  • Dependovirus
  • Disease Models, Animal
  • Female
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • Liver Cirrhosis
  • Male
  • Mice
  • Mice, Knockout
  • Ornithine Carbamoyltransferase
  • Ornithine Carbamoyltransferase Deficiency Disease
  • Treatment Outcome

Disciplines

  • Integrative Biology
  • Systems Biology

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