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Monica Valentovic

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Monica Valentovic

Professor & Research Cluster Coordinator, Pharmacology

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    My educational background has provided an emphasis on pharmacology, pharmacokinetics, drug metabolism and toxicology. I have published over 91 research papers, over 150 abstracts and 4 book chapters on drug pharmacokinetics, toxicity and metabolism of xenobiotics. My graduate education provided a strong background in the area of drug metabolism as well as toxicology. My graduate education included experience with measurement of drug metabolism and pharmacokinetics in cell culture, human samples as well as rodent models. I have considerable experience with HPLC analysis of drugs, biomarkers of oxidative stress, endogenous substances (prostaglandins, ADP and ATP) as well as cellular markers of toxicity. We have considerable experience examining alterations in proteins due to toxicity. My laboratory has 2 Alliance Waters HPLC systems that are dedicated to analysis of pharmaceutical agents, endogenous substances and toxins. Our laboratory is active in examination of the mechanisms of toxicity of drugs and environmental agents in vivo as well as in vitro. I have 91 research publications in the area of pharmacology and toxicology and which provides a strong expertise to direct the studies examining leucine and other amino acids in cell culture media and cell samples. The selected papers in this section depict past experience with antibiotics, HPLC analysis as well as respiratory effects of pulmonary toxins such as ozone and cigarette smoke. The papers below also demonstrate our past experience at examining post-translational modifications of proteins due to increased oxidative stress using HPLC system. I want to mention that I have been on numerous NIH study sections and have Chaired more than 6 NIH study sections which reflects my competency as perceived by my professional colleagues. I also was the 2013 recipient of the Marshall University Distinguished Artist and Scholars Award in Science and Technology award which is given to a faculty member as an achievement of research activity.

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    Disciplines

    • Medical Education
    • Chemical and Pharmacologic Phenomena
    • Medical Pharmacology
    • Medical Toxicology
    • Pharmacy and Pharmaceutical Sciences
    • Medicinal and Pharmaceutical Chemistry
    • Natural Products Chemistry and Pharmacognosy