Research output per year
Research output per year
Personal profile
About
Research Interests
My research interests are to identify the mechanisms of action of omega-3 fatty acids to increase the efficacy and reduce the side effects of cancer chemotherapy and to prevent cancer. It seems so simple, yet there are good biological explanations for the how dietary omega-3 fatty acids can profoundly effect the efficacy of cancer chemotherapeutic agents. These activities include altering: the potential for lipid peroxidation and free radical damage to cancer cells, prostaglandin production in cancer and normal cells, cell membrane fluidity, membrane transport, membrane permeability, the activities of the peroxisome proliferator activated receptor and/or nuclear factor kB, membrane receptor function, estrogen metabolism and the inflammatory process. My future plans include investigating the individual contribution of these mechanisms to increasing the efficacy of cancer chemotherapy in mouse models and in cell culture systems for isolation of independent mechanisms
My research interests are to identify the mechanisms of action of omega-3 fatty acids to increase the efficacy and reduce the side effects of cancer chemotherapy and to prevent cancer. It seems so simple, yet there are good biological explanations for the how dietary omega-3 fatty acids can profoundly effect the efficacy of cancer chemotherapeutic agents. These activities include altering: the potential for lipid peroxidation and free radical damage to cancer cells, prostaglandin production in cancer and normal cells, cell membrane fluidity, membrane transport, membrane permeability, the activities of the peroxisome proliferator activated receptor and/or nuclear factor kB, membrane receptor function, estrogen metabolism and the inflammatory process. My future plans include investigating the individual contribution of these mechanisms to increasing the efficacy of cancer chemotherapy in mouse models and in cell culture systems for isolation of independent mechanisms
Related documents
Disciplines
- Medicine and Health Sciences
Research output
- 28 Article
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Student Perceptions of Nutrition Education at Marshall University Joan C. Edwards School of Medicine: A Resource Challenged Institution
Hardman, W. E., Miller, B. L. & Shah, D. T., Jan 1 2015, In: Biochemistry and Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularity
Cameron, I. L., Markov, M. S., Hardman, W. E. & Hardman, E., Jan 1 2014, In: Biochemistry and Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Inhibition of Cholinergic Signaling Causes Apoptosis in Human Bronchioalveolar Carcinoma
Lau, J. K., Brown, K. C., Thornhill, B. A., Crabtree, C. M., Dom, A. M., Witte, T. R., Hardman, W. E., McNees, C. A., Stover, C. A., Carpenter, A. B., Luo, H., Chen, Y. C., Shiflett, B. S. & Dasgupta, P., Feb 15 2013, In: Biochemistry and Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Consumption of High ω-3 fatty Acid Diet Suppressed Prostate Tumorigenesis in C3(1) Tag Mice
Akinsete, J. A., Ion, G., Witte, T. R. & Hardman, W. E., Jan 1 2012, In: Biochemistry and Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
MG624, an a7-nAChR Antagonist, Inhibits Angiogenesis via the Egr-1/FGF2 Pathway
Brown, K. C., Lau, J. K., Dom, A. M., Witte, T. R., Luo, H., Crabtree, C. M., Shah, Y. H., Shiflett, B. S., Marcelo, A. J., Proper, N. A., Hardman, W. E., Egleton, R. D., Chen, Y. C., Mangiarua, E. I. & Dasgupta, P., Mar 1 2012, In: Biochemistry and Microbiology.Research output: Contribution to journal › Article › peer-review